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A quick analysis shows that there is a huge amount of packet-loss. It does not seem to be MTU related, as the advertised MSS is working fine for a lot of packets and the segments missing seem to be of the same size (1452).
This leaves me to think there is a really bad link between you and the server somewhere. Or, based on your mtupath output, there could be multiple paths from the server towards you where one path has a lower MTU. It does need to be a packet switched path though, as normally loadbalancing over links is done flow based so that all packets follow the same path.
You could try to set your MTU size to a really low value (you mtupath output suggests to use 1024 instead of the current 1492). If that helps, you might want to increase it till it breaks again and keep using that MTU as a workaround.